cicatrix

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	158
interventional	144
Observational	11
Registry	3

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	41
Procedure	25
Drug|placebo	21
Drug	20
Other	13
Biological|placebo	4
Biological	3
Drug|Procedure	3
Other|placebo	3
Device|Procedure	2
Other|Procedure	2
Biological|Procedure	1
Device|Drug	1
Device|Other	1
Drug|Other	1
Drug|placebo|Procedure	1
Other|Radiation	1
placebo|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	56
United Kingdom	17
China	8
NA	8
Canada	7
Denmark	6
Belgium	5
Cuba	4
Egypt	3
Germany	3
Korea, Republic of	3
Turkey	3
Brazil	2
India	2
Netherlands	2
Poland	2
Sweden	2
Austria	1
Belgium|Latvia|Lithuania|United Kingdom	1
France	1
Mexico	1
Poland|United Kingdom	1
Singapore	1
Spain	1
Taiwan	1
Thailand	1
United States|Denmark|France|Germany|Hungary|Italy|Latvia|Poland|Spain|United Kingdom	1
United States|Germany|Hungary|Spain	1

Sites per Study

Site_count	Study_Count
1	123
2	4
3	5
4	1
5	2
7	3
9	2
10	1
21	1
40	1
47	1

Phase

Phase	Study_Count
N/A	80
Phase 2	26
Phase 1	11
Phase 4	10
Phase 1/Phase 2	9
Phase 3	4
Phase 2/Phase 3	3
Early Phase 1	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	24
2	88
3	12
4	7
5	1
6	2
8	1
9	1
NA	8

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	10	4.0000	10.00000	15.00000	14.00000	17.00000	90.00	12.0
1st Qu.	10	17.7500	15.50000	20.00000	41.00000	38.50000	90.00	20.0
Median	10	26.0000	24.00000	35.00000	74.50000	60.00000	126.50	29.0
Mean	10	52.2875	34.36364	44.66667	77.38462	66.33333	173.25	37.9
3rd Qu.	10	60.0000	51.50000	43.00000	102.00000	91.00000	209.75	54.5
Max.	10	435.0000	70.00000	103.00000	175.00000	122.00000	350.00	90.0

Trial Group Type

group_type	Group_Count
Experimental	125
Active Comparator	77
Placebo Comparator	45
Other	25
No Intervention	21
NA	8
Sham Comparator	5

Intervention Model

intervention_model	Study_Count
Parallel Assignment	91
Single Group Assignment	46
Crossover Assignment	4
NA	2
Factorial Assignment	1

Primary Purpose

primary_purpose	Study_Count
Treatment	117
Prevention	17
Basic Science	4
Other	2
Supportive Care	2
NA	2

Observational Studies

Studies by Country

Country	Study_Count
United States	3
Austria	1
Belgium	1
Denmark	1
Egypt	1
Italy	1
Korea, Republic of	1
Netherlands	1
Taiwan	1

Sites per Study

Site_count	Study_Count
1	11

Enrollment Metrics

Measure	Observational
Min	8.0000
1st Qu	20.0000
Median	35.0000
Mean	156.7273
3rd Qu	125.5000
Max	876.0000

Observation Model

observational_model	Study_Count
Case-Control	4
Cohort	2
NA	2
Case-Only	1
Case Control	1
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	5
Retrospective	4
Cross-Sectional	2

Registries

Studies by Country

Country	Study_Count
China	1
Finland	1
United States	1

Sites per Study

Site_count	Study_Count
1	2
2	1

Enrollment Metrics

Measure	Registries
Min	34.0000
1st Qu	117.0000
Median	200.0000
Mean	211.3333
3rd Qu	300.0000
Max	400.0000

Registry Model

observational_model	Study_Count
Cohort	2
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	2
Cross-Sectional	1

Follow-up

target_duration	Study_Count
1 Year	1
10 Years	1
2 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03346668	Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia	https://ClinicalTrials.gov/show/NCT03346668	Recruiting	University of Minnesota	2020-08-01
NCT02985151	Interventional Study to Evaluate the Appearance of Surgical Scars After Laser Therapy	https://ClinicalTrials.gov/show/NCT02985151	Active, not recruiting	St. Louis University	2020-12-31
NCT03380845	Comparison of 1,550-nm Laser and Fractional Radiofrequency Microneedle for the Treatment of Acne Scars in Ethnic Skin	https://ClinicalTrials.gov/show/NCT03380845	Completed	Massachusetts General Hospital	2018-10-30
NCT02651298	CO2-laser Treatment for Caesarean Section Scars	https://ClinicalTrials.gov/show/NCT02651298	Completed	Bispebjerg Hospital	2015-01-31
NCT03352297	Nanofat in Post Burn Scars on the Face	https://ClinicalTrials.gov/show/NCT03352297	Completed	King Edward Medical University	2016-12-31
NCT03257514	Effect of Alpha Lipoic Acid on Uterine Scar Healing After Cesarean Section	https://ClinicalTrials.gov/show/NCT03257514	Completed	Ain Shams University	2018-01-01
NCT03197649	CO2 Laser Phototherapy for Management of Mature Burn Scars	https://ClinicalTrials.gov/show/NCT03197649	Recruiting	University of California, Davis	2022-05-31
NCT03181087	Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars	https://ClinicalTrials.gov/show/NCT03181087	Recruiting	Maternal and Child Health Hospital of Foshan	2021-10-31
NCT03170596	Comparison Between Microneedling Daycare Procedure and Tazarotene 0.1% Gel Local Application in Acne Scarring	https://ClinicalTrials.gov/show/NCT03170596	Completed	Postgraduate Institute of Medical Education and Research	2018-02-28
NCT03078686	Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata	https://ClinicalTrials.gov/show/NCT03078686	Recruiting	Regeneris Medical	2025-01-22
NCT03057964	PDL and Fractional Photothermolysis for Postsurgical Scars	https://ClinicalTrials.gov/show/NCT03057964	Enrolling by invitation	Northwestern University	2021-12-31
NCT03039803	Impact of Double-layer Versus Single-layer Uterine Closure Suture in Cesarean Section on the Development of Postoperative Uterine Scar Deficiency	https://ClinicalTrials.gov/show/NCT03039803	Recruiting	Medical University of Vienna	2019-09-30
NCT02988622	Comparison of Lasers in the Treatment of Scars	https://ClinicalTrials.gov/show/NCT02988622	Completed	University of Iowa	2018-01-15
NCT02968459	Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars	https://ClinicalTrials.gov/show/NCT02968459	Recruiting	Maternal and Child Health Hospital of Foshan	2021-10-31
NCT02898350	Surgical Scar Treatment With the Pulsed Dye Laser in Combination With a CO2 Laser	https://ClinicalTrials.gov/show/NCT02898350	Completed	Syneron Medical	2016-02-29
NCT02886988	Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection	https://ClinicalTrials.gov/show/NCT02886988	Completed	Xijing Hospital	2017-12-28
NCT02861248	Fractional Microplasma Radiofrequency Technology for Non-hypertrophic Post-burn Scars in Asians: A Prospective Study of 95 Patients	https://ClinicalTrials.gov/show/NCT02861248	Completed	Shanghai Jiao Tong University School of Medicine	2014-03-31
NCT02772289	Perinatal Tissue Mesenchyme Stem Cells in the Treatment for Caesarean Section Scars	https://ClinicalTrials.gov/show/NCT02772289	Completed	Maternal and Child Health Hospital of Foshan	2018-09-30
NCT02708628	The Efficacy of Extract of Allium Cepae, Allantoin and Heparin in Patients With Proven Scar Development	https://ClinicalTrials.gov/show/NCT02708628	Completed	Suleymaniye Birth And Women’s Health Education And Research Hospital	2016-04-30
NCT02707627	Laser Therapy for Pediatric Burn Scars	https://ClinicalTrials.gov/show/NCT02707627	Recruiting	The Hospital for Sick Children	2020-07-31
NCT02676115	Medipore Tape Study	https://ClinicalTrials.gov/show/NCT02676115	Completed	NYU Langone Health	2016-02-29
NCT02646917	SkinPen Efficacy on Acne Scars on the Face and/or Back	https://ClinicalTrials.gov/show/NCT02646917	Completed	Bellus Medical, LLC	2016-12-31
NCT02645773	Early Intervention With Non-ablative Fractional Laser to Reduce Cutaneous Scarring	https://ClinicalTrials.gov/show/NCT02645773	Completed	Bispebjerg Hospital	2015-12-31
NCT02643628	A Pilot Study to Evaluate the Safety and Effectiveness of Microneedling and Bellafill to Treat Facial Acne Scars	https://ClinicalTrials.gov/show/NCT02643628	Completed	Suneva Medical, Inc.	2017-06-05
NCT02630303	High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin	https://ClinicalTrials.gov/show/NCT02630303	Completed	VA Northern California Health Care System	2017-03-31
NCT02623829	Botulinum Toxin is a Potential Prophylactic Therapy for Minimizing Post-excisional Scarring (Allergan Botox Scar Study)	https://ClinicalTrials.gov/show/NCT02623829	Completed	Icahn School of Medicine at Mount Sinai	2019-03-01
NCT02472405	Multiplex Laser vs. PDL (Pulsed Dye Laser ) in the Treatment of Surgical Scars	https://ClinicalTrials.gov/show/NCT02472405	Completed	University of Miami	2016-11-30
NCT02397564	Treatment of Post-Surgical Scars With Traditional Ablative Er:YAG Versus Fractional Ablative Er:YAG	https://ClinicalTrials.gov/show/NCT02397564	Completed	University of Louisville	2016-07-31
NCT02396290	Clinical Effect of Platelet Rich Plasma Combined With Laser on Scar	https://ClinicalTrials.gov/show/NCT02396290	Completed	Seoul National University Hospital	2013-09-30
NCT02357095	UACE Followed by Uterine Suction Curettage for the Treatment of Caesarean Scar Pregnancy	https://ClinicalTrials.gov/show/NCT02357095	Completed	Maternal and Child Health Hospital of Hubei Province	2014-06-30
NCT02338388	Cesarean-scar Thickness and Closure Technique	https://ClinicalTrials.gov/show/NCT02338388	Completed	Charite University, Berlin, Germany	2014-04-30
NCT02340325	FS2 Safety and Tolerability Study in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT02340325	Completed	British Columbia Professional Firefighters’ Burn and Wound Healing Laboratory	2016-01-31
NCT02216864	Effect of Multiple Subcisions on Rolling Acne Scars	https://ClinicalTrials.gov/show/NCT02216864	Active, not recruiting	Northwestern University	2020-12-31
NCT02174393	Microneedling Plus the Universal Peel For Acne Scarring	https://ClinicalTrials.gov/show/NCT02174393	Completed	Englewood Hospital and Medical Center	2015-12-31
NCT02120781	Controlled Study to Evaluate the Safety and Efficacy of Azficel-T for the Treatment of Vocal Fold Scarring and Age-Related Dysphonia	https://ClinicalTrials.gov/show/NCT02120781	Completed	Fibrocell Technologies, Inc.	2016-04-30
NCT02115646	Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance	https://ClinicalTrials.gov/show/NCT02115646	Completed	Massachusetts General Hospital	2017-01-31
NCT02103816	The Smartlipo Triplex 1440nm Wavelength Laser and the Sidelaze 800 Hand Piece for the Treatment of Facial Acne Scars	https://ClinicalTrials.gov/show/NCT02103816	Completed	Cynosure, Inc.	2015-02-28
NCT02103127	Evaluation of the Picosure 755nm Alexandrite Laser With Lens Array for the Treatment of Acne Scars	https://ClinicalTrials.gov/show/NCT02103127	Completed	Cynosure, Inc.	2015-05-31
NCT02088567	Amniotic Membrane in Total Knee Replacements to Reduce Scarring	https://ClinicalTrials.gov/show/NCT02088567	Completed	MiMedx Group, Inc.	2014-10-31
NCT02063243	Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars	https://ClinicalTrials.gov/show/NCT02063243	Completed	VU University Medical Center	2012-01-31
NCT02050126	Caesarean Scar Revision With the UltraPulse	https://ClinicalTrials.gov/show/NCT02050126	Completed	Lumenis Ltd.	2016-01-31
NCT02033824	Amniotic Membrane in Decompressive Craniectomy to Reduce Scarring	https://ClinicalTrials.gov/show/NCT02033824	Completed	MiMedx Group, Inc.	2018-06-30
NCT02032641	Evaluation of Non-Ablative Laser for Treatment of Direct Brow Lift Scars	https://ClinicalTrials.gov/show/NCT02032641	Completed	University of Miami	2015-05-31
NCT02014298	Non Ablative Fractional Laser Treatment of Burn Scars	https://ClinicalTrials.gov/show/NCT02014298	Completed	Bispebjerg Hospital	2012-10-31
NCT01976260	A Pilot Study Testing Fractional Radiofrequency Versus Fractional Photothermolysis for the Treatment of Acne Scars	https://ClinicalTrials.gov/show/NCT01976260	Active, not recruiting	Northwestern University	2021-12-31
NCT01958450	Comparison of the Efficacy of Fractional Er:YAG Laser for Acne Scar	https://ClinicalTrials.gov/show/NCT01958450	Completed	Seoul National University Hospital	2013-05-31
NCT01910896	Effectiveness and Safety Study of Overnight Intensive Patch in Scars	https://ClinicalTrials.gov/show/NCT01910896	Completed	Merz Pharmaceuticals GmbH	2015-05-31
NCT01807455	An Open, Non-comparative Study of the Efficacy and Safety of Treatment of Acne Scars With Restylane Vital Lidocaine	https://ClinicalTrials.gov/show/NCT01807455	Completed	Q-Med AB	2014-12-31
NCT01789346	Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars	https://ClinicalTrials.gov/show/NCT01789346	Completed	Cutera Inc.	2014-07-31
NCT01780077	Evaluation of Safety, PK, and Preliminary Effects on Scar Formation of Multiple Intradermal Administrations of RXI-109	https://ClinicalTrials.gov/show/NCT01780077	Completed	RXi Pharmaceuticals, Corp.	2014-06-30
NCT01730339	Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery	https://ClinicalTrials.gov/show/NCT01730339	Completed	Pfizer	2014-10-31
NCT01711060	A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix	https://ClinicalTrials.gov/show/NCT01711060	Completed	Poitiers University Hospital	2014-01-31
NCT01706848	Celotres for Improvement in Wound Healing and Resulting Scar Consequences Following Suturing of a Wound	https://ClinicalTrials.gov/show/NCT01706848	Completed	Halscion, Inc.	2014-05-31
NCT01696513	Effect of Subcision and Suction on Acne Scars	https://ClinicalTrials.gov/show/NCT01696513	Active, not recruiting	Northwestern University	2020-12-31
NCT01644435	A Pilot Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Treatment of Acne Scarring	https://ClinicalTrials.gov/show/NCT01644435	Completed	Kasiak Research Pvt. Ltd.	2012-10-31
NCT01640912	Evaluation of the Safety, Pharmacokinetics, and Preliminary Effect on Scar Formation by RXI-109	https://ClinicalTrials.gov/show/NCT01640912	Completed	RXi Pharmaceuticals, Corp.	2014-04-30
NCT01619917	The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars	https://ClinicalTrials.gov/show/NCT01619917	Active, not recruiting	University of Manitoba	2020-06-30
NCT01504061	Mederma to Reduce Appearance of Post Surgical Scars	https://ClinicalTrials.gov/show/NCT01504061	Completed	Merz North America, Inc.	2012-06-30
NCT01494922	Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001	https://ClinicalTrials.gov/show/NCT01494922	Completed	Pfizer	2013-09-30
NCT01488240	The Role of Pulsed Dye Laser Therapy in the Management of Burn Scars	https://ClinicalTrials.gov/show/NCT01488240	Active, not recruiting	University of Manitoba	2020-06-30
NCT01438125	MF-4181 for the Reduction of Scars Secondary to Abdominoplasty or Laparoscopy/Laparotomy Gynecologic Procedures	https://ClinicalTrials.gov/show/NCT01438125	Completed	Halscion, Inc.	2011-05-31
NCT01413789	Measurement and Comparison of the Occlusive and Hydrating Capacity of Three Silicone Gels and One Gel Cream	https://ClinicalTrials.gov/show/NCT01413789	Completed	University Hospital, Ghent	2012-07-31
NCT01410175	Comparison of the Impact of Electric Scalpels Versus Cold Scalpels	https://ClinicalTrials.gov/show/NCT01410175	Completed	Barretos Cancer Hospital	2012-07-31
NCT01358838	Ablative 10600 nm Fractional Laser Therapy for the Treatment of Scars	https://ClinicalTrials.gov/show/NCT01358838	Completed	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2011-12-31
NCT01346969	Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery	https://ClinicalTrials.gov/show/NCT01346969	Completed	Pfizer	2012-04-30
NCT04389164	Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds	https://ClinicalTrials.gov/show/NCT04389164	Recruiting	First Affiliated Hospital, Sun Yat-Sen University	2025-12-31
NCT04379219	Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy	https://ClinicalTrials.gov/show/NCT04379219	Recruiting	Mansoura University	2020-08-31
NCT04186273	Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2.	https://ClinicalTrials.gov/show/NCT04186273	Recruiting	University of British Columbia	2021-02-01
NCT04169490	“A Clinical Study Investigating the Effectiveness of OTC Scar-management Modalities”	https://ClinicalTrials.gov/show/NCT04169490	Recruiting	The Center for Clinical and Cosmetic Research	2021-01-27
NCT04168125	Use of Tilapia Skin for Palate Repair and Protection After Graft Removal	https://ClinicalTrials.gov/show/NCT04168125	Recruiting	University of Sao Paulo	2020-04-23
NCT04066946	Study for the Effects of Microcurrent Therapy on the Prevention and Healing of Brachioplasty Scars	https://ClinicalTrials.gov/show/NCT04066946	Enrolling by invitation	Organisation for Burns, Scar Aftercare and Research	2021-04-30
NCT04034615	The Long-term Effect of Perinatal Tissue Mesenchyme Stem Cells in the Treatment for Caesarean Section Scars	https://ClinicalTrials.gov/show/NCT04034615	Recruiting	Maternal and Child Health Hospital of Foshan	2021-12-01
NCT03982862	Botulinum Toxins Intralesional Injection for Scar Pain	https://ClinicalTrials.gov/show/NCT03982862	Recruiting	Kaohsiung Medical University	2019-06-30
NCT03936309	A Comparison of Scar Infiltration, Scar Deactivation, and Standard of Care for the Treatment of Chronic, Post-Surgical Pain After Cesarean Section	https://ClinicalTrials.gov/show/NCT03936309	Recruiting	375th Medical Group, Scott Air Force Base	2024-05-31
NCT03915847	Evaluation of Cesarean Scar After Three Different Uterine Closure Technis	https://ClinicalTrials.gov/show/NCT03915847	Completed	Ataturk University	2020-04-16
NCT03901417	Comparison of 1550nm Fractional Laser Alone Versus in Combination With Microneedling for the Treatment of Acne Scars	https://ClinicalTrials.gov/show/NCT03901417	Active, not recruiting	Massachusetts General Hospital	2020-06-30
NCT03887208	Therapy of Scars and Cutis Laxa With Autologous Adipose Derived Mesenchymal Stem Cells	https://ClinicalTrials.gov/show/NCT03887208	Completed	Medical University of Warsaw	2019-01-31
NCT03880058	Safety and Efficacy of SLI-F06 in Wound Healing and Scar Appearance	https://ClinicalTrials.gov/show/NCT03880058	Active, not recruiting	Scarless Laboratories, Inc.	2020-12-30
NCT03850925	Comparison of Picosecond Pulsed Nd:YAG Laser and Fractional Laser for the Treatment of Acne Scars	https://ClinicalTrials.gov/show/NCT03850925	Recruiting	Dongtan Sacred Heart Hospital	2020-04-30
NCT03842644	Postoperative Skin Surface Tension Relaxing in Prevention of Facial Surgical Skin Scarring	https://ClinicalTrials.gov/show/NCT03842644	Recruiting	Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University	2020-09-01
NCT03795116	Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention	https://ClinicalTrials.gov/show/NCT03795116	Active, not recruiting	State University of New York - Downstate Medical Center	2020-05-31
NCT03782038	Study to Evaluate the Efficacy of a Micro Coring Device for the Treatment of Scars of the Cytrellis Micro-Coring Device for the Treatment of Scars	https://ClinicalTrials.gov/show/NCT03782038	Recruiting	Cytrellis Biosystems, Inc.	2019-09-17
NCT03767153	Clinical Evaluation of Fractional Radiofrequency for the Treatment of Acne Scarring	https://ClinicalTrials.gov/show/NCT03767153	Active, not recruiting	Venus Concept	2019-10-05
NCT03664505	Evaluation of the Product Properties of Individualized 3D-compression Garments to Treat Scars	https://ClinicalTrials.gov/show/NCT03664505	Completed	University of Schleswig-Holstein	2018-11-09
NCT03644433	Impact of Uterine Closure Techniques on the Cesarean Scar Thickness After Repeated Cesarean Section	https://ClinicalTrials.gov/show/NCT03644433	Recruiting	Ataturk University	2019-04-30
NCT03627650	Fat Grafting in Skin-grafted Deep Burn Scars	https://ClinicalTrials.gov/show/NCT03627650	Completed	University Hospital, Ghent	2016-09-10
NCT03601247	Silicone Gel for Postsurgical Scars of the Eyelid	https://ClinicalTrials.gov/show/NCT03601247	Recruiting	Montefiore Medical Center	2020-08-01
NCT03569267	A Study to Evaluate Safety and PK Profiles of OLX10010 in Healthy Subjects	https://ClinicalTrials.gov/show/NCT03569267	Completed	Olix Pharmaceuticals, Inc.	2019-06-27
NCT03514615	A Trial to Assess the Safety and Efficacy of Topical Salbutamol in Healthy Volunteers.	https://ClinicalTrials.gov/show/NCT03514615	Completed	University Hospitals, Leicester	2018-07-20
NCT03469830	The Development and Application of “Scar-care” Padding on Management of Hypertrophic Scar	https://ClinicalTrials.gov/show/NCT03469830	Completed	The Hong Kong Polytechnic University	2016-11-01
NCT03467724	Treatment of Surgical Scars Following Breast Augmentation, Abdominoplasty or Face Lift	https://ClinicalTrials.gov/show/NCT03467724	Recruiting	Venus Concept	2020-03-31
NCT03433664	Carbon Dioxide Laser Treatment in Burn-related Scarring	https://ClinicalTrials.gov/show/NCT03433664	Completed	The University of Western Australia	2015-01-16
NCT04456127	CO2 Laser Revision for Burn Related Donor Site Scars	https://ClinicalTrials.gov/show/NCT04456127	Recruiting	Medstar Health Research Institute	2021-07-01
NCT03416660	Efficacy of Different Densities of Fractional Carbon Dioxide in Treatment of Post Burn Scars	https://ClinicalTrials.gov/show/NCT03416660	Completed	Cairo University	2017-12-01
NCT01264588	The Effects of Topical Calcium Glycerophosphate on Surgical Wound Healing and Residual Scarring	https://ClinicalTrials.gov/show/NCT01264588	Completed	AkPharma Inc.	2010-10-31
NCT01217567	Subcuticular Suture Versus Staples for Closure of the Skin After Caesarean Section.	https://ClinicalTrials.gov/show/NCT01217567	Completed	Holbaek Sygehus	2011-07-31
NCT01201525	Pulsed Dye Laser Treatment of Recent Surgical Scars	https://ClinicalTrials.gov/show/NCT01201525	Completed	University Hospital, Ghent	2011-08-31
NCT01176448	Laser Resurfacing Versus Dermabrasion for Scar Revision	https://ClinicalTrials.gov/show/NCT01176448	Completed	University of Minnesota	2010-08-31
NCT01112371	Contractubex Treatment in Scars After Abdominal Caesarean Section	https://ClinicalTrials.gov/show/NCT01112371	Completed	Merz Pharmaceuticals GmbH	2012-02-29
NCT01091181	The Effect of Hysterotomy Technique on the Rate of Large Defects in the Hysterotomy Scar	https://ClinicalTrials.gov/show/NCT01091181	Completed	Region Skane	2016-12-01
NCT01056211	1540nm Non Ablative Fractional Laser Treatment of Scars	https://ClinicalTrials.gov/show/NCT01056211	Completed	University Hospital, Ghent	2013-08-31
NCT01038297	Safety and Efficacy Study of Different Dose Levels of EXC 001 to Improve the Appearance of Scars in Subjects Undergoing Elective Abdominoplasty	https://ClinicalTrials.gov/show/NCT01038297	Completed	Pfizer	2010-07-31
NCT01037413	Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery	https://ClinicalTrials.gov/show/NCT01037413	Completed	Pfizer	2010-12-31
NCT01018589	Cicatrix Cream in Post Surgical Scars and Epidermic Burn	https://ClinicalTrials.gov/show/NCT01018589	Completed	Catalysis SL	2010-12-31
NCT01018212	Cicatrix Cream in Cutaneous Groves	https://ClinicalTrials.gov/show/NCT01018212	Completed	Catalysis SL	2010-12-31
NCT00993005	CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars	https://ClinicalTrials.gov/show/NCT00993005	Completed	Catalysis SL	2010-12-31
NCT00991367	CICATRIX in the Treatment of Recent Post-surgical Scars	https://ClinicalTrials.gov/show/NCT00991367	Completed	Catalysis SL	2010-12-31
NCT00984854	Investigation Into the Safety of Intradermal Juvidex (M6P) Administered to Wounds of Healthy Subjects	https://ClinicalTrials.gov/show/NCT00984854	Completed	Renovo	2004-07-31
NCT00984646	Investigation Into the Scar Reduction Potential of Prevascar (Interleukin-10)	https://ClinicalTrials.gov/show/NCT00984646	Completed	Renovo	2006-11-30
NCT00984581	Safety and Efficacy Study of Avotermin (Juvista) in Female Subjects	https://ClinicalTrials.gov/show/NCT00984581	Completed	Renovo	2004-08-31
NCT00984503	Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites	https://ClinicalTrials.gov/show/NCT00984503	Completed	Renovo	2006-01-31
NCT00984386	Investigation of the Efficacy of Zesteem in Accelerating Early Wound Healing	https://ClinicalTrials.gov/show/NCT00984386	Completed	Renovo	2005-04-30
NCT00978367	Investigation of the Safety, Dosing Frequency and Anti-Scarring Potential of Two Concentrations of Intradermal Avotermin (Juvista)	https://ClinicalTrials.gov/show/NCT00978367	Completed	Renovo	2002-11-30
NCT00978302	Safety Study of Repeated, Escalating Doses of Intradermal Avotermin (Juvista)	https://ClinicalTrials.gov/show/NCT00978302	Completed	Renovo	2001-08-31
NCT00977951	Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects	https://ClinicalTrials.gov/show/NCT00977951	Completed	Renovo	2003-09-30
NCT00984516	Investigation Into the Safety and Scar-improvement Efficacy of Intradermal Juvidex Dosed Once or Three Times	https://ClinicalTrials.gov/show/NCT00984516	Completed	Renovo	2006-01-31
NCT00974870	A Pilot Study Testing the Efficacy of a Needling Device for the Treatment of Acne Scars	https://ClinicalTrials.gov/show/NCT00974870	Completed	Northwestern University	2010-07-31
NCT00970671	Treatment of Surgical Scars Using the Pulsed Dye Laser	https://ClinicalTrials.gov/show/NCT00970671	Completed	University of California, San Diego	2010-12-31
NCT00969215	Burn Scar Appearance After Treatment With Fractional Carbon Dioxide (CO2) Laser	https://ClinicalTrials.gov/show/NCT00969215	Completed	Moy-Fincher Medical Group	2010-09-30
NCT00852280	Effects of Pulsed-Dyed Laser on Scar Formation	https://ClinicalTrials.gov/show/NCT00852280	Completed	Shriners Hospitals for Children	2011-01-31
NCT00847925	Safety and Efficacy of RN1001(Avotermin) in Healthy Male Subjects	https://ClinicalTrials.gov/show/NCT00847925	Completed	Renovo	2003-09-30
NCT00847795	Efficacy and Safety of Intradermal RN1001 (Avotermin) in Elderly Subjects.	https://ClinicalTrials.gov/show/NCT00847795	Completed	Renovo	2003-06-30
NCT04420442	Scar Resection and Reconstruction With Integra and Split Skin Grafts in Patients With Non-Suicidal Self-Inflicted Scars	https://ClinicalTrials.gov/show/NCT04420442	Recruiting	Berufsgenossenschaftliche Unfallklinik Ludwigshafen	2022-11-30
NCT01221922	Laser Treatment of Acne Scars in Fitzpatrick Skin Types III-VI	https://ClinicalTrials.gov/show/NCT01221922	Completed	Cynosure, Inc.	2012-01-31
NCT00811577	A Phase 2a Study to Evaluate the Safety and Efficacy of AZX100 in Trocar Sites of Arthroscopic Shoulder Surgery Patients	https://ClinicalTrials.gov/show/NCT00811577	Completed	Capstone Therapeutics	2010-12-31
NCT01932359	Rapidly Absorbable Versus Non-absorbable Sutures for Mohs Surgery Repair on the Face: a Randomized Controlled Split-scar Study	https://ClinicalTrials.gov/show/NCT01932359	Completed	University of British Columbia	2014-03-31
NCT03036306	Dose Ranging Study to Evaluate the Safety and Tolerability of SCX-001 Cream in Healthy Volunteers With Induced Dermal Incisions	https://ClinicalTrials.gov/show/NCT03036306	Completed	ScarX Corp	2017-10-02
NCT01981330	Pilot Study of Stem Cell Treatment of Patients With Vocal Fold Scarring	https://ClinicalTrials.gov/show/NCT01981330	Completed	Karolinska University Hospital	2020-02-24
NCT03821324	Clinical Evaluation of Fractional Radiofrequency for the Treatment Acne Scarring	https://ClinicalTrials.gov/show/NCT03821324	Active, not recruiting	Venus Concept	2019-11-01
NCT00754247	A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars	https://ClinicalTrials.gov/show/NCT00754247	Completed	University of Miami	2008-02-29
NCT00742443	Juvista in Scar Revision Surgery of Disfiguring Scars	https://ClinicalTrials.gov/show/NCT00742443	Completed	Renovo	2011-01-31
NCT00651820	Effect of Collagenase on Healing and Scarring	https://ClinicalTrials.gov/show/NCT00651820	Completed	Healthpoint	2009-11-30
NCT00642642	Safety and Efficacy Study of Autologous Fibroblasts in the Treatment of Severe Facial Acne Scarring	https://ClinicalTrials.gov/show/NCT00642642	Completed	Fibrocell Technologies, Inc.	2009-03-31
NCT00629811	Improvement in Scar Appearance Following Injection of Avotermin (Juvista) Into Skin Incisions Made in Healthy Men and Women	https://ClinicalTrials.gov/show/NCT00629811	Completed	Renovo	2007-08-31
NCT00627536	Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions	https://ClinicalTrials.gov/show/NCT00627536	Completed	Renovo	2007-03-31
NCT00607685	5FU vs 5FU With Viscoelastic Formulation for the Prevention of Scarring Post-trabeculectomy	https://ClinicalTrials.gov/show/NCT00607685	Completed	Singapore National Eye Centre	2010-01-31
NCT00594581	Anti-Scarring Efficacy and Safety of Intradermal Juvista (Avotermin) in Healthy Males	https://ClinicalTrials.gov/show/NCT00594581	Completed	Renovo	NA
NCT00585286	Fractional Resurfacing Device for Treatment of Acne Scarring	https://ClinicalTrials.gov/show/NCT00585286	Completed	University of California, Irvine	2008-07-31
NCT00510055	Treatment of Acne Scarring With a Novel Procedure Combination	https://ClinicalTrials.gov/show/NCT00510055	Completed	Northwestern University	2009-07-31
NCT00482144	Study of the Effects of the Pulsed-dye Laser at 585nm and 595nm to Treat Post-operative Scars on Suture-removal Day	https://ClinicalTrials.gov/show/NCT00482144	Completed	University of Miami	2008-01-31
NCT00450775	Evaluation of the Efficacy, Tolerability, and Patient Acceptance of Dermatix Q for the Prevention and Management of Scars	https://ClinicalTrials.gov/show/NCT00450775	Completed	Innovative Medical	2008-03-31
NCT00436449	RN1001(Avotermin) in Scar Improvement Following Breast Augmentation	https://ClinicalTrials.gov/show/NCT00436449	Completed	Renovo	2007-10-31
NCT00430326	Juvista (Avotermin) in Scars Following Varicose Vein Removal	https://ClinicalTrials.gov/show/NCT00430326	Completed	Renovo	2009-01-31
NCT00261963	The Effect of UV-Irradiation on Cutaneous Cicatrices	https://ClinicalTrials.gov/show/NCT00261963	Completed	Bispebjerg Hospital	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03395015	Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations	https://ClinicalTrials.gov/show/NCT03395015	Completed	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2017-07-20
NCT02352623	Quality of Life and Surgical Late Effects of Melanoma Treatment	https://ClinicalTrials.gov/show/NCT02352623	Completed	Herlev Hospital	2016-02-29
NCT02115789	Perceptions of Aesthetic Outcomes of Zigzag and Linear Scars	https://ClinicalTrials.gov/show/NCT02115789	Completed	University of California, Davis	2013-06-30
NCT01994616	Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars	https://ClinicalTrials.gov/show/NCT01994616	Completed	VU University Medical Center	2011-01-31
NCT01970761	Autologous Fat Graft Alleviate Scar Pain	https://ClinicalTrials.gov/show/NCT01970761	Completed	Kaohsiung Medical University Chung-Ho Memorial Hospital	2013-01-31
NCT01688063	Skin Elasticity Measurements of the Face and Surgical Scars Stratified by Age and Skin Type	https://ClinicalTrials.gov/show/NCT01688063	Active, not recruiting	Northwestern University	2020-12-31
NCT04187586	Effect of Extracorporeal Shock Wave Therapy for Burn Scar Charateristics	https://ClinicalTrials.gov/show/NCT04187586	Completed	Hangang Sacred Heart Hospital	2019-12-12
NCT03971968	Observational Study for the Long-Term Effects of a Dermal Substitute on Patients With Facial Burns.	https://ClinicalTrials.gov/show/NCT03971968	Completed	Universitair Ziekenhuis Brussel	2019-02-14
NCT01040104	Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals	https://ClinicalTrials.gov/show/NCT01040104	Completed	Medical University of Vienna	2011-07-31
NCT03780699	Hysteroscopic Evaluation of Cesarean Scar Defect	https://ClinicalTrials.gov/show/NCT03780699	Recruiting	Ain Shams University	2019-04-01
NCT00691769	Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia	https://ClinicalTrials.gov/show/NCT00691769	Completed	Wake Forest University Health Sciences	2012-11-26

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03044782	Barriers to Care and QOL for CCCA Patients	https://ClinicalTrials.gov/show/NCT03044782	Completed	Northwestern University	2017-09-30
NCT02717312	Prevalence, Risk Factors and Consequences Related to Cesarean Scar Defect (Defect in Cesarean Scar)	https://ClinicalTrials.gov/show/NCT02717312	Active, not recruiting	Tampere University Hospital	2017-09-30
NCT04096677	Effects of Hysteroscopy and Transvaginal Surgery on Reproductive Prognosis in Patients With Post Cesarean Scar Defect	https://ClinicalTrials.gov/show/NCT04096677	Recruiting	First Affiliated Hospital, Sun Yat-Sen University	2019-09-30